What are polynucleotides?
Polynucleotides (PDRN) are purified DNA fragments derived from salmon, which is remarkably compatible with human tissue. Injected into the skin, they act as regenerative signals — repairing damaged cells, stimulating fibroblasts, boosting collagen and elastin, and deeply hydrating tissue from within.
Are polynucleotides good for dark circles?
Yes — the under-eye area is where polynucleotides truly shine. Unlike filler, which can look puffy in this delicate zone, polynucleotides regenerate the thin under-eye skin itself: improving dark circles, fine lines, crepey texture and mild hollowing for a naturally refreshed look.
How are polynucleotides different from filler?
Filler adds volume; polynucleotides repair and regenerate. They improve skin quality, elasticity, hydration and tone rather than filling a space — which is why they're considered safer and more natural-looking in delicate areas like under the eyes.
How many sessions will I need?
A typical protocol is 2–3 sessions spaced 2–4 weeks apart, followed by maintenance every 6–9 months. Your doctor-led consultation will confirm the right plan for your skin.
When will I see results?
Some brightness and hydration is often visible within days. The main regenerative results — improved dark circles, firmer skin, smoother texture — build over 3–6 weeks after each session as collagen production increases.
Does it hurt?
Numbing cream is applied beforehand and the injections are superficial with very fine needles. Most patients describe only mild, brief stinging. The under-eye area may show small bumps for 24–48 hours which settle naturally.
Is there any downtime?
Minimal. You may have small injection-point bumps, mild redness or light bruising for 24–72 hours, especially under the eyes. Most patients return to normal activities the same day.
How much do polynucleotides cost in London?
London clinics typically charge £250–£400 per session. At Vital Skin & Laser, a single session (face or eyes) is £250 — and because polynucleotides work best as a course of 2–3 sessions, our course rates drop to £179 per session for eyes and £199 per session for face.
